Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial.
Identifieur interne : 000367 ( Main/Exploration ); précédent : 000366; suivant : 000368Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial.
Auteurs : Bálint Er Ss [Hongrie] ; Zsolt Molnár [Hongrie, Pologne] ; Zsolt Szakács [Hongrie] ; Noémi Zádori [Hongrie] ; Lajos Szak [Hongrie] ; Szilárd Váncsa [Hongrie] ; Márk Félix Juhász [Hongrie] ; Klementina Ocskay [Hongrie] ; N Ra Vörhendi [Hongrie] ; Katalin Márta [Hongrie] ; Andrea Szentesi [Hongrie] ; Andrea Párniczky [Hongrie] ; Péter J. Hegyi [Hongrie] ; Szabolcs Kiss [Hongrie] ; Mária Földi [Hongrie] ; Fanni Dembrovszky [Hongrie] ; Anna Kanjo [Hongrie] ; Piroska Pázmány [Hongrie] ; András Varr [Hongrie] ; Árpád Csath [Hongrie] ; Zsuzsanna Helyes [Hongrie] ; Zoltán Péterfi [Hongrie] ; Lászl Czopf [Hongrie] ; István Kiss [Hongrie] ; Antal Zemplényi [Hongrie] ; D Ra Czapári [Hongrie] ; Eszter Hegyi [Hongrie] ; Dalma Dobszai [Hongrie] ; Em Ke Mikl S [Hongrie] ; Attila Márta [Hongrie] ; Dominika T Th [Hongrie] ; Richard Farkas [Hongrie] ; Nelli Farkas [Hongrie] ; Béla Birkás [Hongrie] ; Erika Pintér [Hongrie] ; Gábor Peth [Hongrie] ; Borbála Zsigmond [Hongrie] ; Andrea Sárközi [Hongrie] ; Anik Nagy [Hongrie] ; Péter Hegyi [Hongrie]Source :
- Trials [ 1745-6215 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Appréciation des risques (MeSH), Betacoronavirus (pathogénicité), Comportement alimentaire (MeSH), Comportement de réduction des risques (MeSH), Connaissances, attitudes et pratiques en santé (MeSH), Consommation d'alcool (effets indésirables), Essais cliniques adaptatifs comme sujet (MeSH), Essais cliniques pragmatiques comme sujet (MeSH), Exercice physique (MeSH), Facteurs de protection (MeSH), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Fumer (effets indésirables), Hongrie (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (prévention et contrôle), Infections à coronavirus (virologie), Interactions hôte-pathogène (MeSH), Mâle (MeSH), Pandémies (prévention et contrôle), Pneumopathie virale (diagnostic), Pneumopathie virale (mortalité), Pneumopathie virale (prévention et contrôle), Pneumopathie virale (virologie), Santé mentale (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Éducation pour la santé (MeSH), État de santé (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- effets indésirables : Consommation d'alcool, Fumer.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- pathogénicité : Betacoronavirus.
- prévention et contrôle : Infections à coronavirus, Pandémies, Pneumopathie virale.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Adulte d'âge moyen, Appréciation des risques, Comportement alimentaire, Comportement de réduction des risques, Connaissances, attitudes et pratiques en santé, Essais cliniques adaptatifs comme sujet, Essais cliniques pragmatiques comme sujet, Exercice physique, Facteurs de protection, Facteurs de risque, Facteurs âges, Femelle, Hongrie, Humains, Interactions hôte-pathogène, Mâle, Santé mentale, Sujet âgé, Sujet âgé de 80 ans ou plus, Éducation pour la santé, État de santé.
- Wicri :
- geographic : Hongrie.
English descriptors
- KwdEn :
- Adaptive Clinical Trials as Topic (MeSH), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Alcohol Drinking (adverse effects), Betacoronavirus (pathogenicity), Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Exercise (MeSH), Feeding Behavior (MeSH), Female (MeSH), Health Education (MeSH), Health Knowledge, Attitudes, Practice (MeSH), Health Status (MeSH), Host-Pathogen Interactions (MeSH), Humans (MeSH), Hungary (MeSH), Male (MeSH), Mental Health (MeSH), Middle Aged (MeSH), Pandemics (prevention & control), Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Pneumonia, Viral (prevention & control), Pneumonia, Viral (virology), Pragmatic Clinical Trials as Topic (MeSH), Protective Factors (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH), Risk Reduction Behavior (MeSH), Smoking (adverse effects).
- MESH :
- geographic : Hungary.
- adverse effects : Alcohol Drinking, Smoking.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adaptive Clinical Trials as Topic, Age Factors, Aged, Aged, 80 and over, Exercise, Feeding Behavior, Female, Health Education, Health Knowledge, Attitudes, Practice, Health Status, Host-Pathogen Interactions, Humans, Male, Mental Health, Middle Aged, Pragmatic Clinical Trials as Topic, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior.
Abstract
BACKGROUND
Early reports indicate that COVID-19 may require intensive care unit (ICU) admission in 5-26% and overall mortality can rise to 11% of the recognised cases, particularly affecting the elderly. There is a lack of evidence-based targeted pharmacological therapy for its prevention and treatment. We aim to compare the effects of a World Health Organization recommendation-based education and a personalised complex preventive lifestyle intervention package (based on the same WHO recommendation) on the outcomes of the COVID-19.
METHODS
PROACTIVE-19 is a pragmatic, randomised controlled clinical trial with adaptive "sample size re-estimation" design. Hungarian population over the age of 60 years without confirmed COVID-19 will be approached to participate in a telephone health assessment and lifestyle counselling voluntarily. Volunteers will be randomised into two groups: (A) general health education and (B) personalised health education. Participants will go through questioning and recommendation in 5 fields: (1) mental health, (2) smoking habits, (3) physical activity, (4) dietary habits, and (5) alcohol consumption. Both groups A and B will receive the same line of questioning to assess habits concerning these topics. Assessment will be done weekly during the first month, every second week in the second month, then monthly. The composite primary endpoint will include the rate of ICU admission, hospital admission (longer than 48 h), and mortality in COVID-19-positive cases. The estimated sample size is 3788 subjects per study arm. The planned duration of the follow-up is a minimum of 1 year.
DISCUSSION
These interventions may boost the body's cardiovascular and pulmonary reserve capacities, leading to improved resistance against the damage caused by COVID-19. Consequently, lifestyle changes can reduce the incidence of life-threatening conditions and attenuate the detrimental effects of the pandemic seriously affecting the older population.
TRIAL REGISTRATION
The study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (IV/2428- 2 /2020/EKU) and has been registered at clinicaltrials.gov ( NCT04321928 ) on 25 March 2020.
DOI: 10.1186/s13063-020-04733-0
PubMed: 32993779
PubMed Central: PMC7522906
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Department of Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Parniczky, Andrea" sort="Parniczky, Andrea" uniqKey="Parniczky A" first="Andrea" last="Párniczky">Andrea Párniczky</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hegyi, Peter J" sort="Hegyi, Peter J" uniqKey="Hegyi P" first="Péter J" last="Hegyi">Péter J. 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Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Doctoral School of Clinical Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Foldi, Maria" sort="Foldi, Maria" uniqKey="Foldi M" first="Mária" last="Földi">Mária Földi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Doctoral School of Clinical Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Dembrovszky, Fanni" sort="Dembrovszky, Fanni" uniqKey="Dembrovszky F" first="Fanni" last="Dembrovszky">Fanni Dembrovszky</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Kanjo, Anna" sort="Kanjo, Anna" uniqKey="Kanjo A" first="Anna" last="Kanjo">Anna Kanjo</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Pazmany, Piroska" sort="Pazmany, Piroska" uniqKey="Pazmany P" first="Piroska" last="Pázmány">Piroska Pázmány</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Varr, Andras" sort="Varr, Andras" uniqKey="Varr A" first="András" last="Varr">András Varr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Csath, Arpad" sort="Csath, Arpad" uniqKey="Csath A" first="Árpád" last="Csath">Árpád Csath</name><affiliation wicri:level="1"><nlm:affiliation>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Helyes, Zsuzsanna" sort="Helyes, Zsuzsanna" uniqKey="Helyes Z" first="Zsuzsanna" last="Helyes">Zsuzsanna Helyes</name><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Peterfi, Zoltan" sort="Peterfi, Zoltan" uniqKey="Peterfi Z" first="Zoltán" last="Péterfi">Zoltán Péterfi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, 1st Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Infectious Diseases, 1st Department of Medicine, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Czopf, Laszl" sort="Czopf, Laszl" uniqKey="Czopf L" first="Lászl" last="Czopf">Lászl Czopf</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Cardiology, First Department of Medicine, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Kiss, Istvan" sort="Kiss, Istvan" uniqKey="Kiss I" first="István" last="Kiss">István Kiss</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Public Health, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Zemplenyi, Antal" sort="Zemplenyi, Antal" uniqKey="Zemplenyi A" first="Antal" last="Zemplényi">Antal Zemplényi</name><affiliation wicri:level="1"><nlm:affiliation>Health Technology Assessment Center, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Health Technology Assessment Center, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Pharmacoeconomics, Department of Pharmaceutics, Faculty of Pharmacy, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Pharmacoeconomics, Department of Pharmaceutics, Faculty of Pharmacy, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Czapari, D Ra" sort="Czapari, D Ra" uniqKey="Czapari D" first="D Ra" last="Czapári">D Ra Czapári</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Hegyi, Eszter" sort="Hegyi, Eszter" uniqKey="Hegyi E" first="Eszter" last="Hegyi">Eszter Hegyi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculty of Law, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Law, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Dobszai, Dalma" sort="Dobszai, Dalma" uniqKey="Dobszai D" first="Dalma" last="Dobszai">Dalma Dobszai</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Mikl S, Em Ke" sort="Mikl S, Em Ke" uniqKey="Mikl S E" first="Em Ke" last="Mikl S">Em Ke Mikl S</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Marta, Attila" sort="Marta, Attila" uniqKey="Marta A" first="Attila" last="Márta">Attila Márta</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="T Th, Dominika" sort="T Th, Dominika" uniqKey="T Th D" first="Dominika" last="T Th">Dominika T Th</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Farkas, Richard" sort="Farkas, Richard" uniqKey="Farkas R" first="Richard" last="Farkas">Richard Farkas</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Farkas, Nelli" sort="Farkas, Nelli" uniqKey="Farkas N" first="Nelli" last="Farkas">Nelli Farkas</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute Bioanalysis, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Birkas, Bela" sort="Birkas, Bela" uniqKey="Birkas B" first="Béla" last="Birkás">Béla Birkás</name><affiliation wicri:level="1"><nlm:affiliation>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Pinter, Erika" sort="Pinter, Erika" uniqKey="Pinter E" first="Erika" last="Pintér">Erika Pintér</name><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Peth, Gabor" sort="Peth, Gabor" uniqKey="Peth G" first="Gábor" last="Peth">Gábor Peth</name><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Zsigmond, Borbala" sort="Zsigmond, Borbala" uniqKey="Zsigmond B" first="Borbála" last="Zsigmond">Borbála Zsigmond</name><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Sarkozi, Andrea" sort="Sarkozi, Andrea" uniqKey="Sarkozi A" first="Andrea" last="Sárközi">Andrea Sárközi</name><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nagy, Anik" sort="Nagy, Anik" uniqKey="Nagy A" first="Anik" last="Nagy">Anik Nagy</name><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hegyi, Peter" sort="Hegyi, Peter" uniqKey="Hegyi P" first="Péter" last="Hegyi">Péter Hegyi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Foundation, Szeged, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Translational Medicine Foundation, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32993779</idno><idno type="pmid">32993779</idno><idno type="doi">10.1186/s13063-020-04733-0</idno><idno type="pmc">PMC7522906</idno><idno type="wicri:Area/Main/Corpus">000050</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000050</idno><idno type="wicri:Area/Main/Curation">000050</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000050</idno><idno type="wicri:Area/Main/Exploration">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial.</title><author><name sortKey="Er Ss, Balint" sort="Er Ss, Balint" uniqKey="Er Ss B" first="Bálint" last="Er Ss">Bálint Er Ss</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Foundation, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Translational Medicine Foundation, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Molnar, Zsolt" sort="Molnar, Zsolt" uniqKey="Molnar Z" first="Zsolt" last="Molnár">Zsolt Molnár</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesiology and Intensive Therapy, Poznan University for Medical Sciences, Poznan, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Anaesthesiology and Intensive Therapy, Poznan University for Medical Sciences, Poznan</wicri:regionArea><wicri:noRegion>Poznan</wicri:noRegion></affiliation></author><author><name sortKey="Szakacs, Zsolt" sort="Szakacs, Zsolt" uniqKey="Szakacs Z" first="Zsolt" last="Szakács">Zsolt Szakács</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Zadori, Noemi" sort="Zadori, Noemi" uniqKey="Zadori N" first="Noémi" last="Zádori">Noémi Zádori</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Szak, Lajos" sort="Szak, Lajos" uniqKey="Szak L" first="Lajos" last="Szak">Lajos Szak</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Vancsa, Szilard" sort="Vancsa, Szilard" uniqKey="Vancsa S" first="Szilárd" last="Váncsa">Szilárd Váncsa</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Juhasz, Mark Felix" sort="Juhasz, Mark Felix" uniqKey="Juhasz M" first="Márk Félix" last="Juhász">Márk Félix Juhász</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Ocskay, Klementina" sort="Ocskay, Klementina" uniqKey="Ocskay K" first="Klementina" last="Ocskay">Klementina Ocskay</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Vorhendi, N Ra" sort="Vorhendi, N Ra" uniqKey="Vorhendi N" first="N Ra" last="Vörhendi">N Ra Vörhendi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Marta, Katalin" sort="Marta, Katalin" uniqKey="Marta K" first="Katalin" last="Márta">Katalin Márta</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Szentesi, Andrea" sort="Szentesi, Andrea" uniqKey="Szentesi A" first="Andrea" last="Szentesi">Andrea Szentesi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Foundation, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Translational Medicine Foundation, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Parniczky, Andrea" sort="Parniczky, Andrea" uniqKey="Parniczky A" first="Andrea" last="Párniczky">Andrea Párniczky</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hegyi, Peter J" sort="Hegyi, Peter J" uniqKey="Hegyi P" first="Péter J" last="Hegyi">Péter J. Hegyi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Kiss, Szabolcs" sort="Kiss, Szabolcs" uniqKey="Kiss S" first="Szabolcs" last="Kiss">Szabolcs Kiss</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Doctoral School of Clinical Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Foldi, Maria" sort="Foldi, Maria" uniqKey="Foldi M" first="Mária" last="Földi">Mária Földi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Doctoral School of Clinical Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Dembrovszky, Fanni" sort="Dembrovszky, Fanni" uniqKey="Dembrovszky F" first="Fanni" last="Dembrovszky">Fanni Dembrovszky</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Kanjo, Anna" sort="Kanjo, Anna" uniqKey="Kanjo A" first="Anna" last="Kanjo">Anna Kanjo</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Pazmany, Piroska" sort="Pazmany, Piroska" uniqKey="Pazmany P" first="Piroska" last="Pázmány">Piroska Pázmány</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Varr, Andras" sort="Varr, Andras" uniqKey="Varr A" first="András" last="Varr">András Varr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Csath, Arpad" sort="Csath, Arpad" uniqKey="Csath A" first="Árpád" last="Csath">Árpád Csath</name><affiliation wicri:level="1"><nlm:affiliation>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Helyes, Zsuzsanna" sort="Helyes, Zsuzsanna" uniqKey="Helyes Z" first="Zsuzsanna" last="Helyes">Zsuzsanna Helyes</name><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Peterfi, Zoltan" sort="Peterfi, Zoltan" uniqKey="Peterfi Z" first="Zoltán" last="Péterfi">Zoltán Péterfi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases, 1st Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Infectious Diseases, 1st Department of Medicine, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Czopf, Laszl" sort="Czopf, Laszl" uniqKey="Czopf L" first="Lászl" last="Czopf">Lászl Czopf</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Cardiology, First Department of Medicine, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Kiss, Istvan" sort="Kiss, Istvan" uniqKey="Kiss I" first="István" last="Kiss">István Kiss</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Public Health, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Zemplenyi, Antal" sort="Zemplenyi, Antal" uniqKey="Zemplenyi A" first="Antal" last="Zemplényi">Antal Zemplényi</name><affiliation wicri:level="1"><nlm:affiliation>Health Technology Assessment Center, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Health Technology Assessment Center, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Pharmacoeconomics, Department of Pharmaceutics, Faculty of Pharmacy, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Division of Pharmacoeconomics, Department of Pharmaceutics, Faculty of Pharmacy, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Czapari, D Ra" sort="Czapari, D Ra" uniqKey="Czapari D" first="D Ra" last="Czapári">D Ra Czapári</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Hegyi, Eszter" sort="Hegyi, Eszter" uniqKey="Hegyi E" first="Eszter" last="Hegyi">Eszter Hegyi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculty of Law, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Law, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Dobszai, Dalma" sort="Dobszai, Dalma" uniqKey="Dobszai D" first="Dalma" last="Dobszai">Dalma Dobszai</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Mikl S, Em Ke" sort="Mikl S, Em Ke" uniqKey="Mikl S E" first="Em Ke" last="Mikl S">Em Ke Mikl S</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Marta, Attila" sort="Marta, Attila" uniqKey="Marta A" first="Attila" last="Márta">Attila Márta</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="T Th, Dominika" sort="T Th, Dominika" uniqKey="T Th D" first="Dominika" last="T Th">Dominika T Th</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Farkas, Richard" sort="Farkas, Richard" uniqKey="Farkas R" first="Richard" last="Farkas">Richard Farkas</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation></author><author><name sortKey="Farkas, Nelli" sort="Farkas, Nelli" uniqKey="Farkas N" first="Nelli" last="Farkas">Nelli Farkas</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute Bioanalysis, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Birkas, Bela" sort="Birkas, Bela" uniqKey="Birkas B" first="Béla" last="Birkás">Béla Birkás</name><affiliation wicri:level="1"><nlm:affiliation>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Pinter, Erika" sort="Pinter, Erika" uniqKey="Pinter E" first="Erika" last="Pintér">Erika Pintér</name><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Peth, Gabor" sort="Peth, Gabor" uniqKey="Peth G" first="Gábor" last="Peth">Gábor Peth</name><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Zsigmond, Borbala" sort="Zsigmond, Borbala" uniqKey="Zsigmond B" first="Borbála" last="Zsigmond">Borbála Zsigmond</name><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Sarkozi, Andrea" sort="Sarkozi, Andrea" uniqKey="Sarkozi A" first="Andrea" last="Sárközi">Andrea Sárközi</name><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nagy, Anik" sort="Nagy, Anik" uniqKey="Nagy A" first="Anik" last="Nagy">Anik Nagy</name><affiliation wicri:level="3"><nlm:affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heim Pál National Pediatric Institute, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hegyi, Peter" sort="Hegyi, Peter" uniqKey="Hegyi P" first="Péter" last="Hegyi">Péter Hegyi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624</wicri:regionArea><wicri:noRegion>H-7624</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Translational Medicine Foundation, Szeged, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Translational Medicine Foundation, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>János Szentágothai Research Centre, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary. p.hegyi@tm-centre.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trials</title><idno type="eISSN">1745-6215</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Clinical Trials as Topic (MeSH)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Alcohol Drinking (adverse effects)</term><term>Betacoronavirus (pathogenicity)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (prevention & control)</term><term>Coronavirus Infections (virology)</term><term>Exercise (MeSH)</term><term>Feeding Behavior (MeSH)</term><term>Female (MeSH)</term><term>Health Education (MeSH)</term><term>Health Knowledge, Attitudes, Practice (MeSH)</term><term>Health Status (MeSH)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Humans (MeSH)</term><term>Hungary (MeSH)</term><term>Male (MeSH)</term><term>Mental Health (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (prevention & control)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (prevention & control)</term><term>Pneumonia, Viral (virology)</term><term>Pragmatic Clinical Trials as Topic (MeSH)</term><term>Protective Factors (MeSH)</term><term>Risk Assessment (MeSH)</term><term>Risk Factors (MeSH)</term><term>Risk Reduction Behavior (MeSH)</term><term>Smoking (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Appréciation des risques (MeSH)</term><term>Betacoronavirus (pathogénicité)</term><term>Comportement alimentaire (MeSH)</term><term>Comportement de réduction des risques (MeSH)</term><term>Connaissances, attitudes et pratiques en santé (MeSH)</term><term>Consommation d'alcool (effets indésirables)</term><term>Essais cliniques adaptatifs comme sujet (MeSH)</term><term>Essais cliniques pragmatiques comme sujet (MeSH)</term><term>Exercice physique (MeSH)</term><term>Facteurs de protection (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Fumer (effets indésirables)</term><term>Hongrie (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (prévention et contrôle)</term><term>Infections à coronavirus (virologie)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (prévention et contrôle)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (prévention et contrôle)</term><term>Pneumopathie virale (virologie)</term><term>Santé mentale (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Éducation pour la santé (MeSH)</term><term>État de santé (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hungary</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Alcohol Drinking</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Consommation d'alcool</term><term>Fumer</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term><term>Pandemics</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à coronavirus</term><term>Pandémies</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptive Clinical Trials as Topic</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Exercise</term><term>Feeding Behavior</term><term>Female</term><term>Health Education</term><term>Health Knowledge, Attitudes, Practice</term><term>Health Status</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Male</term><term>Mental Health</term><term>Middle Aged</term><term>Pragmatic Clinical Trials as Topic</term><term>Protective Factors</term><term>Risk Assessment</term><term>Risk Factors</term><term>Risk Reduction Behavior</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Appréciation des risques</term><term>Comportement alimentaire</term><term>Comportement de réduction des risques</term><term>Connaissances, attitudes et pratiques en santé</term><term>Essais cliniques adaptatifs comme sujet</term><term>Essais cliniques pragmatiques comme sujet</term><term>Exercice physique</term><term>Facteurs de protection</term><term>Facteurs de risque</term><term>Facteurs âges</term><term>Femelle</term><term>Hongrie</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Mâle</term><term>Santé mentale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Éducation pour la santé</term><term>État de santé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hongrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Early reports indicate that COVID-19 may require intensive care unit (ICU) admission in 5-26% and overall mortality can rise to 11% of the recognised cases, particularly affecting the elderly. There is a lack of evidence-based targeted pharmacological therapy for its prevention and treatment. We aim to compare the effects of a World Health Organization recommendation-based education and a personalised complex preventive lifestyle intervention package (based on the same WHO recommendation) on the outcomes of the COVID-19.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>PROACTIVE-19 is a pragmatic, randomised controlled clinical trial with adaptive "sample size re-estimation" design. Hungarian population over the age of 60 years without confirmed COVID-19 will be approached to participate in a telephone health assessment and lifestyle counselling voluntarily. Volunteers will be randomised into two groups: (A) general health education and (B) personalised health education. Participants will go through questioning and recommendation in 5 fields: (1) mental health, (2) smoking habits, (3) physical activity, (4) dietary habits, and (5) alcohol consumption. Both groups A and B will receive the same line of questioning to assess habits concerning these topics. Assessment will be done weekly during the first month, every second week in the second month, then monthly. The composite primary endpoint will include the rate of ICU admission, hospital admission (longer than 48 h), and mortality in COVID-19-positive cases. The estimated sample size is 3788 subjects per study arm. The planned duration of the follow-up is a minimum of 1 year.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>These interventions may boost the body's cardiovascular and pulmonary reserve capacities, leading to improved resistance against the damage caused by COVID-19. Consequently, lifestyle changes can reduce the incidence of life-threatening conditions and attenuate the detrimental effects of the pandemic seriously affecting the older population.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>The study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (IV/2428- 2 /2020/EKU) and has been registered at clinicaltrials.gov ( NCT04321928 ) on 25 March 2020.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32993779</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1745-6215</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>29</Day></PubDate></JournalIssue><Title>Trials</Title><ISOAbbreviation>Trials</ISOAbbreviation></Journal><ArticleTitle>Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial.</ArticleTitle><Pagination><MedlinePgn>809</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13063-020-04733-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Early reports indicate that COVID-19 may require intensive care unit (ICU) admission in 5-26% and overall mortality can rise to 11% of the recognised cases, particularly affecting the elderly. There is a lack of evidence-based targeted pharmacological therapy for its prevention and treatment. We aim to compare the effects of a World Health Organization recommendation-based education and a personalised complex preventive lifestyle intervention package (based on the same WHO recommendation) on the outcomes of the COVID-19.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">PROACTIVE-19 is a pragmatic, randomised controlled clinical trial with adaptive "sample size re-estimation" design. Hungarian population over the age of 60 years without confirmed COVID-19 will be approached to participate in a telephone health assessment and lifestyle counselling voluntarily. Volunteers will be randomised into two groups: (A) general health education and (B) personalised health education. Participants will go through questioning and recommendation in 5 fields: (1) mental health, (2) smoking habits, (3) physical activity, (4) dietary habits, and (5) alcohol consumption. Both groups A and B will receive the same line of questioning to assess habits concerning these topics. Assessment will be done weekly during the first month, every second week in the second month, then monthly. The composite primary endpoint will include the rate of ICU admission, hospital admission (longer than 48 h), and mortality in COVID-19-positive cases. The estimated sample size is 3788 subjects per study arm. The planned duration of the follow-up is a minimum of 1 year.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">These interventions may boost the body's cardiovascular and pulmonary reserve capacities, leading to improved resistance against the damage caused by COVID-19. Consequently, lifestyle changes can reduce the incidence of life-threatening conditions and attenuate the detrimental effects of the pandemic seriously affecting the older population.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">The study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (IV/2428- 2 /2020/EKU) and has been registered at clinicaltrials.gov ( NCT04321928 ) on 25 March 2020.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Erőss</LastName><ForeName>Bálint</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Translational Medicine Foundation, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molnár</LastName><ForeName>Zsolt</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Anaesthesiology and Intensive Therapy, Poznan University for Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szakács</LastName><ForeName>Zsolt</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zádori</LastName><ForeName>Noémi</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szakó</LastName><ForeName>Lajos</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Váncsa</LastName><ForeName>Szilárd</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juhász</LastName><ForeName>Márk Félix</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ocskay</LastName><ForeName>Klementina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vörhendi</LastName><ForeName>Nóra</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Márta</LastName><ForeName>Katalin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szentesi</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Translational Medicine Foundation, Szeged, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Párniczky</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hegyi</LastName><ForeName>Péter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiss</LastName><ForeName>Szabolcs</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Földi</LastName><ForeName>Mária</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dembrovszky</LastName><ForeName>Fanni</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanjo</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pázmány</LastName><ForeName>Piroska</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Heim Pál National Pediatric Institute, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Varró</LastName><ForeName>András</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Csathó</LastName><ForeName>Árpád</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Department of Behavioral Sciences, Medical School, University of Pécs, Pécs, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helyes</LastName><ForeName>Zsuzsanna</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>János Szentágothai Research Centre, University of Pécs, Pécs, 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uniqKey="Molnar Z" first="Zsolt" last="Molnár">Zsolt Molnár</name><name sortKey="Nagy, Anik" sort="Nagy, Anik" uniqKey="Nagy A" first="Anik" last="Nagy">Anik Nagy</name><name sortKey="Ocskay, Klementina" sort="Ocskay, Klementina" uniqKey="Ocskay K" first="Klementina" last="Ocskay">Klementina Ocskay</name><name sortKey="Ocskay, Klementina" sort="Ocskay, Klementina" uniqKey="Ocskay K" first="Klementina" last="Ocskay">Klementina Ocskay</name><name sortKey="Parniczky, Andrea" sort="Parniczky, Andrea" uniqKey="Parniczky A" first="Andrea" last="Párniczky">Andrea Párniczky</name><name sortKey="Parniczky, Andrea" sort="Parniczky, Andrea" uniqKey="Parniczky A" first="Andrea" last="Párniczky">Andrea Párniczky</name><name sortKey="Pazmany, Piroska" sort="Pazmany, Piroska" uniqKey="Pazmany P" first="Piroska" last="Pázmány">Piroska Pázmány</name><name sortKey="Pazmany, Piroska" sort="Pazmany, Piroska" uniqKey="Pazmany P" first="Piroska" last="Pázmány">Piroska Pázmány</name><name sortKey="Pazmany, Piroska" sort="Pazmany, Piroska" uniqKey="Pazmany P" first="Piroska" last="Pázmány">Piroska Pázmány</name><name sortKey="Peterfi, Zoltan" sort="Peterfi, Zoltan" uniqKey="Peterfi Z" first="Zoltán" last="Péterfi">Zoltán Péterfi</name><name sortKey="Peth, Gabor" sort="Peth, Gabor" uniqKey="Peth G" first="Gábor" last="Peth">Gábor Peth</name><name sortKey="Peth, Gabor" sort="Peth, Gabor" uniqKey="Peth G" first="Gábor" last="Peth">Gábor Peth</name><name sortKey="Pinter, Erika" sort="Pinter, Erika" uniqKey="Pinter E" first="Erika" last="Pintér">Erika Pintér</name><name sortKey="Pinter, Erika" sort="Pinter, Erika" uniqKey="Pinter E" first="Erika" last="Pintér">Erika Pintér</name><name sortKey="Sarkozi, Andrea" sort="Sarkozi, Andrea" uniqKey="Sarkozi A" first="Andrea" last="Sárközi">Andrea Sárközi</name><name sortKey="Szak, Lajos" sort="Szak, Lajos" uniqKey="Szak L" first="Lajos" last="Szak">Lajos Szak</name><name sortKey="Szak, Lajos" sort="Szak, Lajos" uniqKey="Szak L" first="Lajos" last="Szak">Lajos Szak</name><name sortKey="Szakacs, Zsolt" sort="Szakacs, Zsolt" uniqKey="Szakacs Z" first="Zsolt" last="Szakács">Zsolt Szakács</name><name sortKey="Szakacs, Zsolt" sort="Szakacs, Zsolt" uniqKey="Szakacs Z" first="Zsolt" last="Szakács">Zsolt Szakács</name><name sortKey="Szentesi, Andrea" sort="Szentesi, Andrea" uniqKey="Szentesi A" first="Andrea" last="Szentesi">Andrea Szentesi</name><name sortKey="Szentesi, Andrea" sort="Szentesi, Andrea" uniqKey="Szentesi A" first="Andrea" last="Szentesi">Andrea Szentesi</name><name sortKey="Szentesi, Andrea" sort="Szentesi, Andrea" uniqKey="Szentesi A" first="Andrea" last="Szentesi">Andrea Szentesi</name><name sortKey="T Th, Dominika" sort="T Th, Dominika" uniqKey="T Th D" first="Dominika" last="T Th">Dominika T Th</name><name sortKey="Vancsa, Szilard" sort="Vancsa, Szilard" uniqKey="Vancsa S" first="Szilárd" last="Váncsa">Szilárd Váncsa</name><name sortKey="Vancsa, Szilard" sort="Vancsa, Szilard" uniqKey="Vancsa S" first="Szilárd" last="Váncsa">Szilárd Váncsa</name><name sortKey="Varr, Andras" sort="Varr, Andras" uniqKey="Varr A" first="András" last="Varr">András Varr</name><name sortKey="Vorhendi, N Ra" sort="Vorhendi, N Ra" uniqKey="Vorhendi N" first="N Ra" last="Vörhendi">N Ra Vörhendi</name><name sortKey="Vorhendi, N Ra" sort="Vorhendi, N Ra" uniqKey="Vorhendi N" first="N Ra" last="Vörhendi">N Ra Vörhendi</name><name sortKey="Zadori, Noemi" sort="Zadori, Noemi" uniqKey="Zadori N" first="Noémi" last="Zádori">Noémi Zádori</name><name sortKey="Zadori, Noemi" sort="Zadori, Noemi" uniqKey="Zadori N" first="Noémi" last="Zádori">Noémi Zádori</name><name sortKey="Zemplenyi, Antal" sort="Zemplenyi, Antal" uniqKey="Zemplenyi A" first="Antal" last="Zemplényi">Antal Zemplényi</name><name sortKey="Zemplenyi, Antal" sort="Zemplenyi, Antal" uniqKey="Zemplenyi A" first="Antal" last="Zemplényi">Antal Zemplényi</name><name sortKey="Zsigmond, Borbala" sort="Zsigmond, Borbala" uniqKey="Zsigmond B" first="Borbála" last="Zsigmond">Borbála Zsigmond</name></country><country name="Pologne"><noRegion><name sortKey="Molnar, Zsolt" sort="Molnar, Zsolt" uniqKey="Molnar Z" first="Zsolt" last="Molnár">Zsolt Molnár</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000367 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000367 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidSeniorV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32993779
|texte= Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial.
}}
Pour générer des pages wiki
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidSeniorV1
| This area was generated with Dilib version V0.6.37. |  |